CNS • Increased basal sympathetic tone • Abnormal stress response Blood Vessels • Abnormal response to baroreceptors • Decreased nitric oxide • Increased endothelin Cfrroemat ethde b Nyo Nuinc kPyr oKjencictky • Ca++ or Na+/K+ channels defects Baroreceptors • Hyper responsiveness to • Desensitization catecholamines • Medial layer hypertrophy Adrenal Cfrroemat ethde b Nyo Aumn ePtrhoyjestc Sttudio Kidney • Catecholamine leak • RAA dysfunction or dysregulation • Ion channel defects