This book discusses parasite biology, antimalarial drugs and their mechanism of action, and the dynamic situation of evolving drug resistance of parasites, which has become a pressing issue. The book provides insight into the plasmodium species, the role of cytokines in activating immune response during malaria infection, the importance of antimalarials as a therapeutic option, issues of drug resistance and co-resistance, and validation of evolved resistance in humanized mouse models. As teachers of parasite biology, we are becoming increasingly aware of the lack of detailed information and experimental approaches about drugs and drug resistance in many medical schools and undergraduate courses. This volume is a timely addition to the existing literature on malaria parasite biology and a useful resource for students, researchers, and those working in the field of parasite biology, drugs, drug resistance of infectious diseases in general, and human malaria parasites in particular and beyond. Contents 1. Finding Novel Strategies to Overcome the Impact of Malaria Vector Resistance in Limited-Resources Settings. The Case of Cameroon as a Basis for Reflection 2. Plasmodium Species and Drug Resistance 3. Recent Advances in Antimalarial Drug Discovery: Challenges and Opportunities 4. Adaptive Drug Resistance in Malaria Parasite: A Threat to Malaria Elimination Agenda? 5. Treatment of Malaria Infection and Drug Resistance 6. P. falciparum and Its Molecular Markers of Resistance to Antimalarial Drugs 7. A Double Line of Defense: Heat Shock Proteins and Polyamines Act as Contributing Factors to Drug Resistance of some Plasmodium Parasites 8. Molecular Approaches for Malaria Therapy 9. Regulation of T-reg/Th-17 Balance: One Step Closer Towards Immunotherapy Against Malaria Infection 10. A Comprehensive Review of 4(1H)-Quinolones and 4(1H)-Pyridones for the Development of an Effective Antimalarial 11. Stable Artesunate Resistance in A Humanized Mouse Model of Plasmodium falciparum 12. Drug Design for Malaria with Artificial Intelligence (AI) 13. Plasmodium vivax and Drug Resistance 14. rRNA Platform Technology for Drug Discovery Methods for Identifying Ligands That Target Plasmodium RNA Structural Motifs 15. Malaria: Introductory Concepts, Resistance Issues and Current Medicines

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