MicroRNAs in Cancer Translational Research William C.S. Cho Editor MicroRNAs in Cancer Translational Research 123 Editor Dr.WilliamC.S.Cho QueenElizabethHospital DepartmentofClinicalOncology 30GascoigneRoad HongKongSAR PRChina [email protected] ISBN978-94-007-0297-4 e-ISBN978-94-007-0298-1 DOI10.1007/978-94-007-0298-1 SpringerDordrechtHeidelbergLondonNewYork ©SpringerScience+BusinessMediaB.V.2011 Nopartofthisworkmaybereproduced,storedinaretrievalsystem,ortransmittedinanyformorby anymeans,electronic,mechanical,photocopying,microfilming,recordingorotherwise,withoutwritten permissionfromthePublisher,withtheexceptionofanymaterialsuppliedspecificallyforthepurpose ofbeingenteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework. Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) Preface MicroRNAs(miRNAs)havearevolutionaryimpactoncancerresearchoverrecent years. These small non-coding RNAs emerge as important players in tumorigene- sis, leading to a paradigm shift in oncology. The rapid discovery of many miRNA targetsandtheirassociatedpathwayshascontributedtothedevelopmentofmiRNA- basedtherapeuticsforcancer.TheseexcitingfindingsrevealthepotentialofmiRNA studiestranslatingfrombenchtobedsideapplications.Thoroughunderstandingof miRNAs in cancer translational research is apparently a prerequisite for all pro- fessionals involved and interested in this area. MiRNA is a cutting-edge topic in the scientific and medical fields, the identification of cancer-related miRNAs and their state-of-the-art treatment approaches proceed at a fast pace. These stimulat- ingadvancesdrovemetocompilethisuniquebookentitledMicroRNAsinCancer TranslationalResearch. HongKong,China WilliamC.S.Cho January2011 v Contents 1 MicroRNAsinCancer(AnOverview) . . . . . . . . . . . . . . . . 1 ManuelaFerracin,GeorgeA.Calin,andMassimoNegrini 2 TheRoleofMicroRNAsinLungCancerDevelopment, Progression,andMetastasis . . . . . . . . . . . . . . . . . . . . . . 73 DonL.Gibbons,ZainH.Rizvi,andJonathanM.Kurie 3 MicroRNAsinBreastCancer . . . . . . . . . . . . . . . . . . . . . 91 Suvi-KatriLeivonen 4 MicroRNAsinColorectalCancer . . . . . . . . . . . . . . . . . . . 107 OndrejSlaby,MarekSvoboda,JaroslavMichalek, andRostislavVyzula 5 MicroRNAsinGastricCancer. . . . . . . . . . . . . . . . . . . . . 135 HidekazuSuzuki,YoshimasaSaito,andToshifumiHibi 6 MicroRNAsinProstateCancer:APossibleRoleasNovel BiomarkersandTherapeuticTargets? . . . . . . . . . . . . . . . . 145 PaoloGandellini,MarcoFolini,andNadiaZaffaroni 7 MicroRNAsinHepatocellularCarcinoma . . . . . . . . . . . . . . 163 JunfangJiandXinWeiWang 8 MicroRNAsinCervicalCarcinoma . . . . . . . . . . . . . . . . . . 189 Jeong-WonLee,Byoung-GieKim,andDuk-SooBae 9 MicroRNAsinEsophagealCancer . . . . . . . . . . . . . . . . . . 201 JianGuandXifengWu 10 MicroRNAsinBladderCancer . . . . . . . . . . . . . . . . . . . . 223 MichaelB.WilliamsandLianaAdam 11 MicroRNAsinLymphoma . . . . . . . . . . . . . . . . . . . . . . . 239 AlbaNavarroLópezandLuisHernándezPous 12 MicroRNAsinLeukemia. . . . . . . . . . . . . . . . . . . . . . . . 269 FlorianKuchenbauer,JohannesBloehdorn,LarsBullinger, andThorstenZenz vii viii Contents 13 MicroRNAs in Pancreatic Cancer: Potential Interests asBiomarkersandTherapeuticTools . . . . . . . . . . . . . . . . 287 PierreCordelierandJérômeTorrisani 14 MicroRNAsinEpithelialOvarianCancer . . . . . . . . . . . . . . 309 ChunshengLi,YiFeng,GeorgeCoukos,andLinZhang 15 MicroRNAsinBrainTumors . . . . . . . . . . . . . . . . . . . . . 343 TaraSpence,JohnnyNguyen,EricBouffet,andAnnieHuang 16 MicroRNAsandCancerStemCells . . . . . . . . . . . . . . . . . . 373 ZuorenYuandRichardG.Pestell 17 MicroRNAsinCancerInvasionandMetastasis . . . . . . . . . . . 389 AshharS.Ali,ShadanAli,AamirAhmad, PhilipA.Philip,andFazlulH.Sarkar 18 MicroRNAsinPredictingRadiotherapyandChemotherapy Response. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 415 EmilyJ.Noonan,RobertF.Place,andLong-ChengLi 19 RoleofMicroRNAsinAnti-cancerDrugResistance . . . . . . . . 449 ErikA.C.Wiemer 20 MicroRNAsandCancerMetabolism . . . . . . . . . . . . . . . . . 485 PingGao 21 MicroRNAsasBlood-basedBiomarkersofCancer . . . . . . . . . 499 XiChen,JunfengZhang,KeZen,andChen-YuZhang 22 RNAi-basedApproachestotheTreatmentofBrainTumors . . . . 533 SarojP.Mathupala,SandeepMittal,MuraliGuthikonda, andAndrewE.Sloan Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 551 Contributors LianaAdamDepartmentofUrology,MDAndersonCancerCenter, TheUniversityofTexas,Houston,TX77030,USA,[email protected] AamirAhmadDepartmentofPathology,KarmanosCancerInstitute,WayneState University,Detroit,MI48201,USA,[email protected] AshharS.AliDepartmentofPathology,KarmanosCancerInstitute,WayneState University,Detroit,MI48201,USA,[email protected] ShadanAliDivisionofHematologyandOncology,KarmanosCancerInstitute, WayneStateUniversity,Detroit,MI48201,USA,[email protected] Duk-SooBaeDepartmentofObstetricsandGynecology,SamsungMedical Center,SungkyunkwanUniversitySchoolofMedicine,Gangnam-gu,Seoul 135-710,Korea,[email protected] JohannesBloehdornDepartmentofInternalMedicineIII,UniversityofUlm, 89081Ulm,Germany,[email protected] EricBouffetPediatricBrainTumourProgram,DivisionofHematologyOncology, SickKidsHospital,Toronto,ON,Canada;DepartmentofPediatrics,Universityof Toronto,Toronto,ON,CanadaM5G1X8,[email protected] LarsBullingerDepartmentofInternalMedicineIII,UniversityofUlm, 89081Ulm,Germany,[email protected] GeorgeA.CalinDepartmentofExperimentalTherapeuticsandCancerGenetics, MDAndersonCancerCenter,UniversityofTexas,Houston,TX77030,USA, [email protected] XiChenStateKeyLaboratoryofPharmaceuticalBiotechnology,SchoolofLife Sciences,JiangsuDiabetesCenter,NanjingUniversity,Nanjing,Jiangsu210093, PRChina,[email protected] PierreCordelierInsermU858,I2MRInstitutdeMédecineMoléculairede Rangueil,BP84225,31432ToulouseCedex4,France,pierre.cordelier@inserm GeorgeCoukosDepartmentofObstetricsandGynecology,AbramsonFamily CancerResearchInstitute,CenterforResearchonEarlyDetectionandCureof ix x Contributors OvarianCancer,UniversityofPennsylvania,Philadelphia,PA19104,USA, [email protected] YiFengAbramsonFamilyCancerResearchInstitute,UniversityofPennsylvania, Philadelphia,PA19104,USA,[email protected] ManuelaFerracinDepartmentofExperimentalandDiagnosticMedicine, UniversityofFerrara,Ferrara44121,Italy,[email protected] MarcoFoliniDepartmentofExperimentalOncologyandMolecularMedicine, FondazioneIRCCSIstitutoNazionaledeiTumori,Milan,Italy, [email protected] PaoloGandelliniMolecularPharmacologyUnit,DepartmentofExperimental OncologyandMolecularMedicine,FondazioneIRCCSIstitutoNazionaledei Tumori,20133Milan,Italy,[email protected] PingGaoDivisionofHematology,DepartmentofMedicine,JohnsHopkins UniversitySchoolofMedicine,Baltimore,MD,USA;SchoolofLifeSciences, UniversityofScienceandTechnologyofChina,Hefei,Anhui230027,PRChina, [email protected];[email protected] DonL.GibbonsDepartmentofThoracic,HeadandNeckMedicalOncologyand Dept.ofMolecular&CellularOncology,MDAndersonCancerCenter, TheUniversityofTexas,Houston,TX77030,USA,[email protected] JianGuDepartmentofEpidemiology,MDAndersonCancerCenter, TheUniversityofTexas,Houston,TX77030,USA,[email protected] MuraliGuthikondaDepartmentofNeurologicalSurgery,KarmanosCancer Institute,WayneStateUniversitySchoolofMedicine,Detroit,MI48201,USA, [email protected] LuisHernándezPousMolecularPathologyDepartment,Facultaddemedicina, Institutd’InvestigacionsBiomèdiquesAugustPiiSunyer(IDIBAPS), 08036Barcelona,Spain,[email protected] ToshifumiHibiDepartmentofInternalMedicine,KeioUniversitySchool ofMedicine,Tokyo160-8582,Japan,[email protected] AnnieHuangPediatricBrainTumourProgram,PrograminCellBiology,Division ofHematologyOncology,DepartmentofPediatrics,SoniaandArthurLabattBrain TumourResearchCentre,HospitalforSickChildren,Toronto,ON, Canada,[email protected] JunfangJiLiverCarcinogenesisSection,LaboratoryofHumanCarcinogenesis, NationalCancerInstitute,CenterforCancerResearch,Bethesda,MD20892-4258, USA,[email protected] Contributors xi Byoung-GieKimDepartmentofObstetricsandGynecology,SamsungMedical Center,SungkyunkwanUniversitySchoolofMedicine,Gangnam-gu, Seoul135-710,Korea,[email protected] FlorianKuchenbauerDepartmentofInternalMedicineIII,UniversityofUlm, 89081Ulm,Germany,fl[email protected] JonathanM.KurieDepartmentofThoracic,HeadandNeckMedicalOncology, MDAndersonCancerCenter,TheUniversityofTexas,Houston,TX77030,USA, [email protected] Jeong-WonLeeDepartmentofObstetricsandGynecology,SamsungMedical Center,SungkyunkwanUniversitySchoolofMedicine,Gangnam-gu, Seoul135-710Korea,[email protected] Suvi-KatriLeivonenVTTMedicalBiotechnology,FI-20521Turku,Finland, suvi-katri.leivonen@vtt.fi ChunshengLiCenterforResearchonEarlyDetectionandCureofOvarian Cancer,UniversityofPennsylvania,Philadelphia,PA19104,USA, [email protected] Long-ChengLiDepartmentofUrology,HelenDillerComprehensiveCancer Center,UniversityofCalifornia,SanFrancisco,CA,USA, [email protected] SarojP.MathupalaDepartmentofNeurologicalSurgery,KarmanosCancer Institute,WayneStateUniversitySchoolofMedicine,Detroit,MI48201,USA, [email protected] JaroslavMichalekFacultyofMedicine,UniversityCellImmunotherapyCenter, MasarykUniversity,62500 Brno,CzechRepublic,[email protected] SandeepMittalDepartmentofNeurologicalSurgery,KarmanosCancerInstitute, WayneStateUniversitySchoolofMedicine,Detroit,MI48201,USA, [email protected] AlbaNavarroLópezMolecularPathologyDepartment,Institutd’Investigacions BiomèdiquesAugustPiiSunyer(IDIBAPS),Barcelona,Spain, [email protected] MassimoNegriniDipartimentodiMedicinaSperimentaleeDiagnostica, UniversitàdiFerrara,Ferrara44121,Italy,[email protected] JohnnyNguyenPrograminCellBiology,SoniaandArthurLabattBrainTumour ResearchCentre,SickKidsHospital,Toronto,ON,CanadaM5G1X8;Department ofLaboratoryMedicineandPathobiology,UniversityofToronto,Toronto,ON, Canada,[email protected]