ةيودلاا ةدام ةثلاثلا ةلحرملا دمحم متاح ريدغ .م .م 2017-2016 Antifungal drugs • Diseases caused by fungi are called Mycoses. • Fungi unlike bacteria they have rigid cell wall contain keratin as well as polysaccharide and cell membrane contain ergosterol rather than cholesterol in mammalian membran. Fungal Cell Structure • Fungi cause slowly progressive chronic infections,however,they may cause life- threatening acute infections in immunoompromised patients (Aids, cancer, Transplant tissuses)so called opportunistic infection. Human mycoses divided into: 1. Superficial mycoses involve (skin, hair, nail). 2. Subcutaneous involve,subcut. Tissues. 3. Systemic mycoses involve internal organs (serious and difficult to treated ). • Fungal infection is benign but it may indicate serious medical conditions • Fungus involved Candida , Aspergillus , Cryptococcus species Candida Aspergillus Cryptococcus species